Mitochondrial Respiration and Atherosclerosis
نویسندگان
چکیده
Atherosclerosis is an underlying cause of various cardiovascular diseases including coronary artery disease, chronic kidney disease, abdominal aortic aneurysm development, stroke, and heart failure. This progressive vascular disease is characterized by subendothelial lipoprotein retention, immune cell infiltration, a maladaptive inflammatory response, and vascular smooth muscle cell (VSMC)–mediated fibrous cap formation. As atherosclerotic lesions progress, cellular and tissue dysfunction give way to cell death and fibrous cap thinning, leading to thrombotic events and plaque rupture.
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